Microfluidics

 

Principle

Microfluidics are devices of sub-millimeter channels for navigating fluids so that an investigation of those can be obtained by certain evaluation methods. One of these methods can be a detection of light intensity emitted by a chemiluminescence reaction. To do so, we use a microfluidc channel with a specific printed antibody in it to capture the particle of interrest which in our case is the heat shock protein. Small scale devices allow a reduction of the amount of liquid needed for testing. This allows us to detect the proteins in a blood plasm sample of less than 100 µL. With a wider channel and a low height we can optimize the surface to volume of blood plasm ratio which leads to a more accurate result. Due to capilary forces the liquids only have to be pipetted into the inlet without utilizing a micropump. As long as the reservoir at the end of the aperture is not filled to the prim, the forces can suck solutions through the channel.

Design

Both the design and the production were carried out by Genspeed Biotech GmbH. The imprinted antibody is currently still in the development phase, which is being conducted at the Technical University of Munich.